San Francisco Giants
San Diego Padres
League : MLB

San Diego Padres vs San Francisco Giants Prediction & Preview


Image licensed from USA Today Sports


The San Francisco Giants and San Diego Padres will finish up a three-game set on Wednesday afternoon at Petco Park. This will be the rubber game of the series with each team winning once, including a 3-1 victory for the Padres as a -185 favorite on Tuesday. San Francisco is off to a 2-3 start on the year after dropping two of three to the Seattle Mariners in its first series, while San Diego is 4-2 after taking three of four from the Arizona Diamondbacks last weekend.

Monday's win snapped a three-game head-to-head winning streak for the Padres, who took the season series 8-2 in 2020.


Giants hope to take series from NL West contender

While the Giants are expected to finish third in a top-heavy NL West, their season series against the heavily favored Padres got off to a good start on Monday night with a 3-2 win before they were shut down on Tuesday. San Francisco opened the scoring with a Brandon Crawford solo homer in the third, but that would be it as it was held to just three hits all night.


A bright spot was Aaron Sanchez returning from an elbow injury to hold San Diego to one run on six hits while striking out four in his first start since August of 2019. Matt Wisler took the loss, giving up two runs in the seventh while recording just one out.

The Giants have a matching 2-3 record against the spread, and cashing in as a +140 underdog in Monday's series opener against the Padres was their best win of the young season. Overs are also 2-3 for the Giants, as their last three games have been pitcher's duels including a 4-0 loss to Seattle in the rubber match of that series.

Entering Tuesday's game, the Giants were averaging exactly four runs per game and had slugged nine home runs, tied with the Houston Astros for the most in the Majors. San Francisco is averaging a 3.86 collective ERA despite giving up eight runs in the Opening Day loss to Seattle.

The Giants will begin their second turn through the rotation on Wednesday with Kevin Gausman getting the ball after a terrific showing on Opening Day, when he held Seattle to one run on two hits over 6.2 innings while striking out six. Evan Longoria is having a resurgent season so far, going 5-17 with three home runs and five RBI.

Relievers John Brebbia and Dedniel Nunez are likely to miss the entire season while recovering from Tommy John surgery. Starter Tyler Beede is progressing towards a return from the procedure himself, while rotation mate Alex Wood is out for a few more weeks due to a back injury.


Padres adjust to life without Tatis Jr.

The big story from Monday's opener wasn't the fact the Padres lost, but superstar shortstop Fernando Tatis Jr. leaving with a shoulder injury that could require a lengthy recovery time. San Diego managed to bounce back on Tuesday, as Eric Hosmer continued his torrid start with an RBI single in the third and Victor Caratini hit a game-winning two-run shot in the seventh to back an excellent pitching performance.


Filling in for Tatis Jr. at shortstop, Ha-Seong Kim had a single, a walk and a run scored. Yu Darvish bounced back from a rough outing on Opening Day, allowing one earned run on just three hits and one walk in seven innings while striking out seven. The Padres bullpen didn't give up a baserunner in three innings, with Keone Kela getting the win and Mark Melancon nailing down his third save.

The Padres are now 3-3 against the spread as they were heavily favored in the Arizona series and were unable to cover the -1.5 runline on Opening Day in an 8-7 victory. Overs are 1-5 for the Padres, with each of their last five games going under the betting total.

The Padres are averaging 4.4 runs per game early on as of Tuesday afternoon, and lead the Majors with a 13.8% walk rate despite the rough game to open this series. San Diego's pitching has been terrific outside of Opening Day, posting a collective 2.2 ERA and 4.64 K/BB.

Offseason acquisition Blake Snell will get the start for San Diego after tossing 4.2 shutout innings against Arizona in his Padres debut, allowing four hits and two walks while racking up eight strikeouts. Hosmer is off to a great start at the plate, going 7-15 with two homers and sevem RBI.

It's still uncertain if Tatis Jr. will undergo surgery that could potentially end his season or just try to rest the injury, but he's going on the 10-day IL and won't be available on Wednesday. The Padres have a whopping 14 players on the IL, with outfielder Trent Grisham (hamstring) and catcher Austin Nola (fractured finger) both also missing from the lineup. Starter Dinelson Lamet is out for an undetermined period of time with elbow discomfort, and rotation mate Mike Clevinger will miss the entire season after undergoing Tommy John surgery.

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